Drug development is a long and costly process, with a high degree of uncertainty from the
identification of a drug target to its market launch. Targeted drugs supported by human …

Cardiometabolic disease has become a major health burden worldwide, with sharply
increasing prevalence but highly limited therapeutic interventions. Emerging evidence has …

Variants of the G protein–coupled receptor 75 (GPR75) are associated with a lower BMI in
large-scale human exome-sequencing studies. However, how GPR75 regulates body …

Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors exert a distinctive pattern of
direct biological effects on the heart and kidney under experimental conditions, but the …

Obesity is a growing public health concern that affects the longevity and lifestyle of all
human populations including children and older individuals. Diverse factors drive obesity …

Approximately 1 in 4 people worldwide have non-alcoholic fatty liver disease (NAFLD);
however, there are currently no medications to treat this condition. This study investigated …

GPR75 is an orphan G protein‐coupled receptor for which there is currently limited
information and its function in physiology and disease is only recently beginning to emerge …

Abstract The south China carp (Cyprinus carpio rubrofuscus) is an indigenous and important
fish species, widely cultured in south China. However, part of individuals experienced …

Obesity and weight regulation disorders are determined by the combined effects of genetics
and environment. Polygenic obesity results from the combination of common variants in …

In a recent article, Leeson-Payne et al. demonstrate that GPR75 knock-out in mice results in
lower body fat and reduced hepatic lipid accumulation, with an increase in physical activity …