The brain is a highly compartmentalized organ exceptionally susceptible to accumulation of
metabolic errors. Alzheimer's disease (AD) is the most prevalent neurodegenerative disease …

BACKGROUND: The iron transport protein of the blood plasma, transferrin, is maintained
only with about 30% of its capacity to bind Fe3+ ions; this leaves the protein the potential …

Identification of new players in iron metabolism, such as hepcidin, which regulates
ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron …

BACKGROUND: For a metal to follow the iron acquisition pathway, four conditions are
required: 1—complex formation with transferrin; 2—interaction with receptor 1; 3—metal …

The role of vanadium binding to transferrin (Tf) in the biological activities of vanadium-based
drugs is a matter of considerable debate. In order to determine whether V (V) and/or V (IV) …

BACKGROUND: Gram negative bacteria require iron for growth and virulence. It has been
shown that certain pathogenic bacteria such as Neisseria gonorrhoeae possess a …

BACKGROUND: In mammals, serum-transferrins transport iron from the neutral environment
of the blood to the cytoplasm by receptor-mediated endocytosis. Extensive in-vitro studies …

Following an internal contamination event, the transport of actinide (An) and lanthanide (Ln)
metal ions through the body is facilitated by endogenous ligands such as the human iron …

Serum transferrin (sTf) transports iron in serum and internalizes in cells via receptor
mediated endocytosis. Additionally, sTf has been identified as the predominant aluminum …

Polyethylene glycol (PEG) has been successfully used for improving circulation time of
several nanomaterials but prolonging the circulation of porous silicon nanoparticles (PSi …