Survey of deep learning in breast cancer image analysis
TG Debelee, F Schwenker, A Ibenthal, D Yohannes - Evolving Systems, 2020 - Springer
Computer-aided image analysis for better understanding of images has been time-honored
approaches in the medical computing field. In the conventional machine learning approach …
approaches in the medical computing field. In the conventional machine learning approach …
Clinical risk management of breast, ovarian, pancreatic, and prostatic cancers for BRCA1/2 variant carriers in Japan
A Ueki, R Yoshida, T Kosaka… - Journal of Human …, 2023 - nature.com
Opportunities for genetic counseling and germline BRCA1/2 (BRCA) testing are increasing
in Japan owing to cancer genomic profiling testing and companion diagnostics being …
in Japan owing to cancer genomic profiling testing and companion diagnostics being …
BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2
The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance
for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly …
for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly …
[HTML][HTML] Classification of VUS and unclassified variants in BRCA1 BRCT repeats by molecular dynamics simulation
Pathogenic mutation in BRCA1 gene is one of the most penetrant genetic predispositions
towards cancer. Identification of the mutation provides important aspect in prevention and …
towards cancer. Identification of the mutation provides important aspect in prevention and …
[HTML][HTML] Classification of 101 BRCA1 and BRCA2 variants of uncertain significance by cosegregation study: a powerful approach
Up to 80% of BRCA1 and BRCA2 genetic variants remain of uncertain clinical significance
(VUSs). Only variants classified as pathogenic or likely pathogenic can guide breast and …
(VUSs). Only variants classified as pathogenic or likely pathogenic can guide breast and …
Germline DNA sequencing reveals novel mutations predictive of overall survival in a cohort of patients with pancreatic cancer
JB Goldstein, L Zhao, X Wang, Y Ghelman… - Clinical Cancer …, 2020 - AACR
Purpose: Family history of BRCA-related tumors may correlate with response to
chemotherapy and overall survival (OS) in pancreatic cancer. The frequency of germline …
chemotherapy and overall survival (OS) in pancreatic cancer. The frequency of germline …
HSF2BP interacts with a conserved domain of BRCA2 and is required for mouse spermatogenesis
I Brandsma, K Sato, SE van Rossum-Fikkert… - Cell reports, 2019 - cell.com
The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication
fork stability, and DNA interstrand crosslink repair in vertebrates. We identify HSF2BP, a …
fork stability, and DNA interstrand crosslink repair in vertebrates. We identify HSF2BP, a …
Large‐scale comparative evaluation of user‐friendly tools for predicting variant‐induced alterations of splicing regulatory elements
H Tubeuf, C Charbonnier, O Soukarieh… - Human …, 2020 - Wiley Online Library
Discriminating which nucleotide variants cause disease or contribute to phenotypic traits
remains a major challenge in human genetics. In theory, any intragenic variant can …
remains a major challenge in human genetics. In theory, any intragenic variant can …
Identification of differentially methylated BRCA1 and CRISP2 DNA regions as blood surrogate markers for cardiovascular disease
Abstract Genome-wide Illumina InfiniumMethylation 450 K DNA methylation analysis was
performed on blood samples from clinical atherosclerosis patients (n= 8) and healthy donors …
performed on blood samples from clinical atherosclerosis patients (n= 8) and healthy donors …
PARP inhibitors for metastatic castration-resistant prostate cancer: Biological rationale and current evidence
Poly (ADP-ribose) polymerase inhibitors (PARPi) are the first clinically approved agents
designed to exploit synthetic lethality. Based on the recent approvals, PARPi became …
designed to exploit synthetic lethality. Based on the recent approvals, PARPi became …