In this paper we present an overview of agent-based models that are used to simulate
mechanical and physiological phenomena in cells and tissues, and we discuss underlying …

A prerequisite for the systems biology analysis of tissues is an accurate digital three-
dimensional reconstruction of tissue structure based on images of markers covering multiple …

Mathematical models are increasingly designed to guide experiments in biology,
biotechnology, as well as to assist in medical decision making. They are in particular …

Three-dimensional multicellular aggregates such as spheroids provide reliable in vitro
substitutes for tissues. Quantitative characterization of spheroids at the cellular level is …

Background and Aims Small‐molecule flux in tissue microdomains is essential for organ
function, but knowledge of this process is scant due to the lack of suitable methods. We …

Diffusion-weighted magnetic resonance imaging (DWI) is a key non-invasive imaging
technique for cancer diagnosis and tumor treatment assessment, reflecting Brownian …

Partial liver removal is an important therapy option for liver cancer. In most patients within a
few weeks, the liver is able to fully regenerate. In some patients, however, regeneration fails …

Many physiological processes and pathological conditions in livers are spatially
heterogeneous, forming patterns at the lobular length scale or varying across the organ …

Cirrhosis represents the end‐stage of any persistent chronically active liver disease. It is
characterized by the complete replacement of normal liver tissue by fibrosis, regenerative …

Computational models of liver metabolism are gaining an increasing importance within the
research community. Moreover, their first clinical applications have been reported in recent …