More than 50 years ago, the first concepts for gastroretentive drug delivery systems were
developed. Despite extensive research in this field, there is no single formulation concept for …

Precipitation of cinnarizine during in vitro lipolysis of a self-microemulsifying drug delivery
system (SMEDDS) was characterized to gain a better understanding of the mechanisms …

The purpose of writing this review on gastroretentive drug delivery systems (GRDDS) was to
compile the recent literature with a special focus on various gastroretentive approaches that …

An oral sustained release dosage form of cinnarizine HCl (CNZ) based on gastric floating
matrix tablets was studied. The release of CNZ from different floating matrix formulations …

In vitro dissolution testing is important for providing process control and quality assurance,
determination of stability release characteristics of the product over time, and facilitating …

A rapid throughput equilibrium solubility measurement is described. The method utilizes
central liquid storage where compounds are stored as 10mM solution in dimethyl sulfoxide …

Background: Interest in gastro-retentive drug delivery systems (GRDDS) can be attributed to
the desire for increased patient convenience (once daily dosing) and to increase the …

Objectives: The objective of the study was to investigate the effect of iron oxide in the
development of mucoadhesive tablets of cinnarizine using Eudragit RLPO polymer. A …

Cinnarizine is a weak base, which can produce supersaturation and precipitation during
gastrointestinal transit, affecting its absorption in vivo. Therefore, it is necessary to …

Background: The dissolution method for certain drugs needs specialized conditions.
Dissolution testing for felodipine extended release (ER) tablets (Plendil® 5 mg) and …