In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …

The combinatorial action of transcription factors drives cell-type-specific gene expression
patterns. However, transcription factor binding and gene regulation occur in the context of …

Nuclear pore complexes (NPCs) are composed of several copies of∼ 30 different proteins
called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the …

Highlights•Nuclear pore complexes and nucleoporins have many transport-independent
functions.•Nuclear pore complexes play key roles in gene expression regulation.•In yeast …

Interactions between the genome and the nuclear pore complex (NPC) have been
implicated in multiple gene regulatory processes, but the underlying logic of these …

Dissecting the myriad regulatory mechanisms controlling eukaryotic transcripts from
production to degradation requires quantitative measurements of mRNA flow across the cell …

Nuclear pore complex components (Nups) have been implicated in transcriptional
regulation, yet what regulatory steps are controlled by metazoan Nups remains unclear. We …

It is striking that within a eukaryotic nucleus, the genome can assume specific
spatiotemporal distributions that correlate with the cell's functional states. Cell identity itself is …

Two related post‐translational modifications, the covalent linkage of Ubiquitin and the Small
Ubiquitin‐related MOdifier (SUMO) to lysine residues, play key roles in the regulation of both …

Highlights•Intron retention is a widespread feature of mammalian gene expression
programs.•Retained introns are associated with post-transcriptional alternative …