Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Platelets play a variety of roles in vascular biology and are best recognized as primary
hemostasis and thrombosis mediators. Platelets have a large number of receptors and …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

Abstract S100A8/A9, also known as “calprotectin” or “MRP8/14,” is an alarmin primarily
secreted by activated myeloid cells with antimicrobial, proinflammatory, and prothrombotic …

Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), also known as coronavirus
disease 2019 (COVID-19)-induced infection, is strongly associated with various …

Mucus layers often provide a unique and multi-functional hydrogel interface between the
epithelial cells of organisms and their external environment. Mucus has exceptional …

Rationale: von Willebrand factor (vWF) mediates platelet adhesion during thrombosis. While
chronic thromboembolic pulmonary hypertension (CTEPH) is associated with increased …

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) plaques, tau tangles, brain
atrophy, and vascular pathology. Vascular defects include cerebrovascular dysfunction …

Arterial dissections, which involve an abrupt tear in the wall of a major artery resulting in the
intramural accumulation of blood, are a family of catastrophic disorders causing major …

With the outbreak of coronavirus disease (COVID-19) caused by novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the world has been facing an …