The cohesin complex controls faithful chromosome segregation by pairing sister chromatids
after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional …

Abstract Deletions, duplications, insertions, inversions, and translocations, collectively called
structural variations (SVs), affect more base pairs of the genome than any other sequence …

One lead genetic risk signal of obesity—the rs1421085 T> C variant within the FTO gene—is
reported to be functional in vitro but lacks evidence at an organism level. Here we …

Rationale: ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide), encoded by
the clustered genes Nppa and Nppb, are important prognostic, diagnostic, and therapeutic …

A rare form of X-linked Charcot-Marie-Tooth neuropathy, CMTX3, is caused by an
interchromosomal insertion occurring at chromosome Xq27. 1. Interestingly, eight other …

The discovery of domains of preferential interaction or Topologically Associating Domains
(TADs) has provided a framework to understand the relation between enhancers and …

Enhancers are cis-regulatory sequences located distally to target genes. These sequences
consolidate developmental and environmental cues to coordinate gene expression in a …

The organs of vertebrate species display a wide variety of morphology. A remaining
challenge in evolutionary developmental biology is to elucidate how vertebrate lineages …

TRPS1 serves as the causative gene for tricho‐rhino phalangeal syndrome, known for its
craniofacial and skeletal abnormalities. The Trps1 gene encodes a protein that represses …

The mammary luminal lineage relies on the common cytokine-sensing transcription factor
STAT5 to establish super-enhancers during pregnancy and initiate a genetic program that …