Cation-π interactions arise as a result of strong attractive forces between positively charged
entities and the π-electron cloud of aromatic groups. The physicochemical characteristics of …

The olfactory sense is the dominant sensory perception for many animals. When Richard
Axel and Linda B. Buck received the Nobel Prize in 2004 for discovering the G protein …

Our sense of smell enables us to navigate a vast space of chemically diverse odour
molecules. This task is accomplished by the combinatorial activation of approximately 400 …

Sensory processing in olfactory systems is organized across olfactory bulb glomeruli,
wherein axons of peripheral sensory neurons expressing the same olfactory receptor co …

G protein-coupled receptors (GPCRs) conserve common structural folds and activation
mechanisms, yet their ligand spectra and functions are highly diverse. This work …

In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect
chemicals present in the environment, and to adapt to various levels of stimulation. The …

How the olfactory system detects and distinguishes odorants with diverse physicochemical
properties and molecular configurations remains poorly understood. Vertebrate animals …

The relative importance of various sensory modalities can shift in response to evolutionary
transitions, resulting in changes to underlying gene families encoding their reception …

Humans have 396 unique, intact olfactory receptors (ORs), G-protein coupled receptors
(GPCRs) containing receptor-specific binding sites; other mammals have more. Activation of …

In the olfactory system, odorant receptors (ORs) expressed at the cell membrane of olfactory
sensory neurons detect odorants and direct sensory axons toward precise target locations in …