Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …

The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol
and corticosterone, act through the structurally similar mineralocorticoid (MR) and …

Hsp90 is a conserved and essential molecular chaperone responsible for the folding and
activation of hundreds of 'client'proteins,–. The glucocorticoid receptor (GR) is a model client …

Nearly 100 proteins are known to be regulated by hsp90. Most of these substrates or “client
proteins” are involved in signal transduction, and they are brought into complex with hsp90 …

The 90-kDa molecular chaperone family (which comprises, among other proteins, the 90-
kDa heat-shock protein, hsp90 and the 94-kDa glucose-regulated protein, grp94, major …

We used a cellular system to elucidate the molecular determinants of the large immunophilin
FK506-binding proteins (FKBP) 51 and-52 for their action on the glucocorticoid receptor in …

Hsp90 is a chaperone required for the conformational maturation of certain signaling
proteins including Raf, cdk4, and steroid receptors. Natural products and synthetic small …

Steroid hormone receptors (SHRs) are notorious intracellular travellers, transiting among
different cellular compartments as they mature, are subjected to regulation and exert their …

Glucocorticoid effects on the human trabecular meshwork can be used as a model system in
which to study glaucomatous damage to the trabecular meshwork. One of the most important …

The ubiquitous protein chaperone hsp90 has been shown to regulate more than 100
proteins involved in cellular signalling. These proteins are called 'client proteins' for hsp90 …