The evolving landscape of pulmonary arterial hypertension clinical trials

J Weatherald, A Boucly, A Peters, D Montani, K Prasad… - The Lancet, 2022 - thelancet.com
Although it is a rare disease, the number of available therapeutic options for treating
pulmonary arterial hypertension has increased since the late 1990s, with multiple drugs …

Risk stratification and treatment goals in pulmonary arterial hypertension

F Dardi, A Boucly, R Benza, R Frantz… - European …, 2024 - publications.ersnet.org
Risk stratification has gained an increasing role in predicting outcomes and guiding the
treatment of patients with pulmonary arterial hypertension (PAH). The most predictive …

[HTML][HTML] Development and validation of an abridged version of the REVEAL 2.0 risk score calculator, REVEAL Lite 2, for use in patients with pulmonary arterial …

RL Benza, MK Kanwar, A Raina, JV Scott, CL Zhao… - Chest, 2021 - Elsevier
Background Achievement of low-risk status is a treatment goal in pulmonary arterial
hypertension (PAH). Risk assessment often is performed using multiparameter tools, such …

BNP/NT-proBNP in pulmonary arterial hypertension: time for point-of-care testing?

RA Lewis, C Durrington, R Condliffe… - European Respiratory …, 2020 - Eur Respiratory Soc
Despite the advent of new therapies and improved outcomes in patients with pulmonary
arterial hypertension (PAH), it remains a life-shortening disease and the time to diagnosis …

Pulmonary hypertension definition, classification, and epidemiology in Asia

JJ Anderson, EM Lau - JACC: Asia, 2022 - jacc.org
Pulmonary hypertension (PH) is caused by a range of conditions and is important to
recognize as it is associated with increased mortality. Pulmonary arterial hypertension refers …

Plasma cell-free DNA predicts survival and maps specific sources of injury in pulmonary arterial hypertension

SB Brusca, JM Elinoff, Y Zou, MK Jang, H Kong… - Circulation, 2022 - Am Heart Assoc
Background: Cell-free DNA (cfDNA) is a noninvasive marker of cellular injury. Its
significance in pulmonary arterial hypertension (PAH) is unknown. Methods: Plasma cfDNA …

[HTML][HTML] Risk assessment in pulmonary arterial hypertension: insights from the GRIPHON study

O Sitbon, KM Chin, RN Channick, RL Benza… - The Journal of Heart and …, 2020 - Elsevier
BACKGROUND Approaches to risk assessment in pulmonary arterial hypertension (PAH)
include the noninvasive French risk assessment approach (number of low-risk criteria based …

Maximal exercise testing using the incremental shuttle walking test can be used to risk-stratify patients with pulmonary arterial hypertension

RA Lewis, CG Billings, JA Hurdman… - Annals of the …, 2021 - atsjournals.org
Rationale: Exercise capacity predicts mortality in pulmonary arterial hypertension (PAH), but
limited data exist on the routine use of maximal exercise testing. Objectives: This study …

Emerging therapies: The potential roles SGLT2 inhibitors, GLP1 agonists, and ARNI therapy for ARNI pulmonary hypertension

NE King, E Brittain - Pulmonary Circulation, 2022 - Wiley Online Library
Pulmonary hypertension (PH) is a highly morbid condition. PH due to left heart disease (PH‐
LHD) has no specific therapies and pulmonary arterial hypertension (PAH) has substantial …

Prognostic value of serial risk stratification in adult and pediatric pulmonary arterial hypertension: a systematic review

C Lokhorst, S van der Werf, RMF Berger… - Journal of the …, 2024 - ahajournals.org
Background In pulmonary arterial hypertension, it is recommended to base therapeutic
decisions on risk stratification. This systematic review aims to report the prognostic value of …