Skeletal muscle adapts its mass as consequence of physical activity, metabolism and
hormones. Catabolic conditions or inactivity induce signaling pathways that regulate the …

Prolonged skeletal muscle inactivity (eg limb immobilization, bed rest, mechanical
ventilation, spinal cord injury, etc.) results in muscle atrophy that manifests into a decreased …

Objective To determine the prevalence of hypermetabolism, relative to body composition, in
amyotrophic lateral sclerosis (ALS) and its relationship with clinical features of disease and …

Loss of skeletal muscle mass is a characteristic feature of various pathologies including
cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the …

How mitochondrial DNA mutations clonally expand in an individual cell is a question that
has perplexed mitochondrial biologists for decades. A growing body of literature indicates …

Muscle loss during aging and disuse is a highly prevalent and disabling condition, but
knowledge about cellular pathways mediating muscle atrophy is still limited. Given the …

Rationale: Peripheral nerve injury is common in clinic, which leads to severe atrophy and
dysfunction of the denervated muscles, but the underlying mechanism is not fully …

Skeletal muscle is a tissue with a low mitochondrial content under basal conditions, but it is
responsive to acute increases in contractile activity patterns (ie exercise) which initiate the …

In humans, nutrient deprivation and extreme endurance exercise both activate autophagy.
We hypothesized that cumulating fasting and cycling exercise would potentiate activation of …

Sarcopenia is associated with increased levels of apoptosis (47) and reduced capabilities
for muscle regeneration (41) leading to muscle wasting. For this reason, many studies …