The intricacies of the 3D hierarchical organization of the genome have been approached by
many creative modeling studies. The specific model/simulation technique combination …

Chromosome conformation capture technologies that provide frequency information for
contacts between genomic regions have been crucial for increasing our understanding of …

ABSTRACT Three-dimensional (3D) organization of the human genome plays an essential
role in all DNA-templated processes, including gene transcription, gene regulation, and …

Nucleosomes form heterogeneous groups in vivo, named clutches. Clutches are smaller
and less dense in mouse embryonic stem cells (ESCs) compared to neural progenitor cells …

Nucleosomes cluster together when chromatin folds in the cell to form heterogeneous
groups termed “clutches”. These structural units add another level of chromatin regulation …

The complex role of linker histone (LH) on chromatin compaction regulation has been
highlighted by recent discoveries of the effect of LH binding variability and isoforms on …

Gene regulation programs establish cellular identity and rely on dynamic changes in the
structural packaging of genomic DNA. The DNA is packaged in chromatin, which is formed …

Euchromatin is an accessible phase of genetic material containing genes that encode
proteins with increased expression levels. The structure of euchromatin in vitro has been …

The relationship between chromatin architecture and function defines a central problem in
biology and medicine. Many computational chromatin models with atomic, coarse-grained …

The nuclear envelope segregates the genome of Eukaryota from the cytoplasm. Within the
nucleus, chromatin is further compartmentalized into architectures that change throughout …