It has been generally accepted that insulin resistance (IR) and reduced insulin secretory
capacity are the basic pathogenesis of type 2 diabetes mellitus (T2DM). In addition to …

We determined the relationships between metabolic score for IR (METS-IR), triglyceride-
glucose (TyG) index, and homeostatic model assessment for IR (HOMA-IR) and incident …

Background: Non-alcoholic fatty liver disease is a chronic disease caused by the
accumulation of fat in the liver related to overweight and obesity, insulin resistance …

Background Measures of insulin resistance (IR)/sensitivity (IS) are emerging tools to identify
metabolic-associated fatty liver disease (MAFLD). However, the comprehensive assessment …

Background Luseogliflozin, a sodium–glucose cotransporter 2 inhibitor, potentially exerts
pleiotropic effects on the liver. However, the sufficient evidence is still lacking. We aimed to …

Purpose Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are
frequently co-occurring diseases. Liver fibrosis (LF), with increasing incidence, has a …

Background Prevention and treatment of liver fibrosis at an early stage is of great prognostic
importance, whereas changes in liver stiffness are often overlooked in patients before the …

Aim Left ventricular diastolic dysfunction (LVDD) has been observed in people with
nonalcoholic fatty liver disease (NAFLD) in cross-sectional studies but the causal …

Nonalcoholic fatty liver disease (NAFLD), which has recently undergone a change in its
definition and acronym to “metabolic dysfunction-associated fatty liver disease (MAFLD),” is …

Both metabolic disease and chronic stress contributes to the pathogenesis of at least seven
of the ten leading causes of death in the developed world, including cardiovascular disease …