Targeted therapy is a new cancer treatment approach, involving drugs that particularly target
specific proteins in cancer cells, such as receptor tyrosine kinases (RTKs) which are …

Integrin adhesions are a structurally and functionally diverse family of transmembrane, multi-
protein complexes that link the intracellular cytoskeleton to the extracellular matrix (ECM) …

Background: Bisphenol A (BPA) is a synthetic plasticizer that is commonly used in the
production of polycarbonate plastics and epoxy resins. Human exposure occurs when BPA …

Highlights•Several lines of preclinical evidence link the Axl/Gas6 protein system to colorectal
cancer.•Axl overexpression is a negative prognostic factor in colorectal cancer.•Drugs …

ABSTRACT AXL, a receptor tyrosine kinase (RTK), plays a pivotal role in various cellular
functions. It is primarily involved in processes such as epithelial-mesenchymal transition …

The invasive phenotype of metastatic cancer cells is accompanied by the formation of actin-
rich invadopodia, which adhere to the extracellular matrix and degrade it. In this study, we …

Background: Head and neck cancer (HNC) is a major cause of morbidity and mortality and
has a poor treatment outcome. Irinotecan, a topoisomerase-I inhibitor, induces cell death by …

There is an ample epidemiological evidence to support the role of environmental
contaminants such as bisphenol A (BPA) in breast cancer development but the molecular …

Axl has emerged as an attractive target for cancer therapy due to its strong correlation with
tumor growth, metastasis, poor survival, and drug resistance. Herein, we report the design …

Pollution is a critical concern of modern society for its heterogeneous effects on human
health, despite a widespread lack of awareness. Environmental pollutants promote several …