Ankylosing spondylitis: an autoimmune or autoinflammatory disease?
Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …
Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
[HTML][HTML] Role of the IL-23/IL-17 pathway in rheumatic diseases: an overview
C Schinocca, C Rizzo, S Fasano, G Grasso… - Frontiers in …, 2021 - frontiersin.org
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …
[HTML][HTML] The role of natural killer cells in autoimmune diseases
UC Kucuksezer, E Aktas Cetin, F Esen… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …
lymphoid progenitors, were discovered in early 1970's. They are members of innate …
[HTML][HTML] T cells in health and disease
L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal Transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
Ankylosing spondylitis and axial spondyloarthritis
JD Taurog, A Chhabra, RA Colbert - New England Journal of …, 2016 - Mass Medical Soc
Ankylosing Spondylitis and Axial Spondyloarthritis | NEJM Skip to main content NEJM Group
Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a physician, build …
Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a physician, build …
[HTML][HTML] The MHC locus and genetic susceptibility to autoimmune and infectious diseases
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
Pathogenesis of ankylosing spondylitis—recent advances and future directions
V Ranganathan, E Gracey, MA Brown… - Nature Reviews …, 2017 - nature.com
Over the past 5 years, advances in high-throughput techniques and studies involving large
cohorts of patients have led to considerable advances in the identification of novel genetic …
cohorts of patients have led to considerable advances in the identification of novel genetic …
The causes and consequences of genetic interactions (epistasis)
J Domingo, P Baeza-Centurion… - Annual review of …, 2019 - annualreviews.org
The same mutation can have different effects in different individuals. One important reason
for this is that the outcome of a mutation can depend on the genetic context in which it …
for this is that the outcome of a mutation can depend on the genetic context in which it …
[PDF][PDF] 10 years of GWAS discovery: biology, function, and translation
Application of the experimental design of genome-wide association studies (GWASs) is now
10 years old (young), and here we review the remarkable range of discoveries it has …
10 years old (young), and here we review the remarkable range of discoveries it has …