Interferon regulatory factor 5 (IRF5) belongs to a family of transcription factors, originally
implicated in antiviral responses and interferon production. However, studies conducted in …

The interferon regulatory factors (IRFs) are a family of master transcription factors that
regulate pathogen-induced innate and acquired immune responses. Aberration (s) in IRF …

Chronic graft-versus-host disease (cGVHD) is a debilitating, autoimmune-like syndrome that
can occur after allogeneic hematopoietic stem cell transplantation. Constitutively activated B …

Sepsis is a deadly condition lacking a specific treatment despite decades of research. This
has prompted the exploration of new approaches, with extracellular vesicles (EVs) emerging …

Acute lung injury (ALI) with uncontrolled inflammatory response has high morbidity and
mortality rates in critically ill patients. Pathogen-associated molecular patterns (PAMPs) are …

Inhibitory oligodeoxynucleotides (ODNs) are short single-stranded DNA, which capable of
folding into complex structures, enabling them to bind to a large variety of targets. With …

Objective To investigate the functional consequences of the single‐nucleotide
polymorphism rs4648889 in a putative enhancer upstream of the RUNX3 promoter …

Co-delivery of chemical drugs and nucleic acids has attracted a great interest recently for
treatment of inflammatory diseases. Dasatinib (DB), a tyrosine kinase inhibitor with anti …

The resistance in microorganisms against many conventional antibiotics has become a
serious global health problem. However, antibacterial drug delivery materials are still limited …

Abstract Manganese (Mn 2+) has been reported to activate macrophages and NK cells, and
to induce the production of type-I interferons (IFNs) by activating the cGAS-STING pathway …