The elucidation of the three dimensional structure of biological macromolecules has
provided an important contribution to our current understanding of many basic mechanisms …

Protein crystallization has been known since 1840 and can prove to be straightforward but,
in most cases, it constitutes a real bottleneck. This stimulated the birth of the …

The Machine Recognition of Crystallization Outcomes (MARCO) initiative has assembled
roughly half a million annotated images of macromolecular crystallization experiments from …

The availability of whole-genome sequence data, made possible by significant advances in
DNA sequencing technology, led to the emergence of structural genomics projects in the …

The crystal growth kinetics of a proprietary active pharmaceutical ingredient (API) was
investigated by isothermal seeded batch de-supersaturation experiments in solvent mixtures …

While crystallization historically predates crystallography, it is a critical step for the
crystallographic process. The rich history of crystallization and how that history influences …

The use of protein X-ray crystallography for structure-based design of small-molecule drugs
is well-documented and includes several notable success stories. However, it is less well …

Crystallography may be the gold standard of protein structure determination, but obtaining
the necessary high-quality crystals is also in some ways akin to prospecting for the precious …

While protein crystallization has broadly been applied to determine the 3D structure of
proteins, it has recently drawn great attention to replace the traditional downstream …

The REMARK280 field of the Protein Data Bank is the richest open source of successful
crystallization information. The REMARK280 field is optional and currently uncurated, so …