The most frequent recurring mutations in neurofibromatosis type 1 (NF1) are large deletions
encompassing the NF1 gene and its flanking regions (NF1 microdeletions). The majority of …

The DNA damage response network guards the stability of the genome from a plethora of
exogenous and endogenous insults. An essential feature of the DNA damage response …

Small-molecule inhibitors of PARP1/2, such as olaparib, have been proposed to serve as a
synthetic lethal therapy for cancers that harbor BRCA1 or BRCA2 mutations. Indeed, in …

Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer
(EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 …

The NCI-60 cell lines are the most frequently studied human tumor cell lines in cancer
research. This panel has generated the most extensive cancer pharmacology database …

The ring-shaped complex PCNA coordinates DNA replication, encircling DNA to act as a
polymerase clamp and a sliding platform to recruit other replication proteins. PCNA is …

Protein ubiquitination and deubiquitination are central to the control of a large number of
cellular pathways and signaling networks in eukaryotes. Although the essential roles of …

Genome instability via RNA: DNA hybrid-mediated R loops has been observed in mutants
involved in various aspects of transcription and RNA processing. The prevalence of this …

Bromodomain-containing proteins bind acetylated lysine residues on histone tails and are
involved in the recruitment of additional factors that mediate histone modifications and …

Inhibitors of poly (ADP-ribose) polymerase (PARP) have demonstrated efficacy in women
with BRCA-mutant ovarian cancer. However, only 15%–20% of ovarian cancers harbor …