The pathways that deliver newly synthesized proteins that reside in lysosomes are well
understood on comparison with our knowledge of how integral membrane proteins are …

MicroRNAs (miRNAs) are implicated in both tissue differentiation and maintenance of tissue
identity. In most cases, however, the mechanisms underlying their regulation are not known …

The maintenance of cellular homeostasis and execution of regulatory mechanisms to
dynamically govern various cellular processes require the correct delivery of proteins to their …

Abnormal proliferation and phenotypic modulation of pulmonary artery smooth muscle cells
(PASMC) contributes to the pathogenesis of numerous cardiovascular disorders, including …

The nonreceptor tyrosine kinase Src is frequently overexpressed and/or activated in human
colorectal carcinoma (CRC), and its increased activity has been associated with a poor …

The inhibitor of the nuclear factor-κB (IκB) kinase (IKK) complex is a key regulator of the
canonical NF-κB signalling cascade and is crucial for fundamental cellular functions …

Lysosomal degradation of ubiquitinated transmembrane protein receptors (cargo) relies on
the function of Endosomal Sorting Complex Required for Transport (ESCRT) protein …

The endosomal sorting complexes required for transport (ESCRTs) machinery consists of
four protein assemblies (ESCRT-0 to-III subcomplexes) which mediate various processes of …

Active Src localization at focal adhesions (FAs) is essential for cell migration. How this pool
is linked mechanistically to the large pool of Src at late endosomes (LEs)/lysosomes (LY) is …

Different molecular signaling pathways, biological processes, and intercellular
communication mechanisms control longevity and are affected during cellular senescence …