Infections in the etiology of Parkinson's disease and synucleinopathies: A renewed perspective, mechanistic insights, and therapeutic implications

G Mercado, C Kaeufer, F Richter… - Journal of Parkinson's …, 2024 - journals.sagepub.com
Increasing evidence suggests a potential role for infectious pathogens in the etiology of
synucleinopathies, a group of age-related neurodegenerative disorders including …

[HTML][HTML] Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19

A Vanderheiden, MS Diamond - Viruses, 2025 - mdpi.com
Post-acute sequelae of COVID-19 (PASC) are a diverse set of symptoms and syndromes
driven by dysfunction of multiple organ systems that can persist for years and negatively …

[HTML][HTML] Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia

ML Wu, C Xie, X Li, J Sun, J Zhao… - Frontiers in Cellular and …, 2024 - frontiersin.org
SARS-CoV-2-induced excessive inflammation in brain leads to damage of blood-brain
barrier, hypoxic-ischemic injury, and neuron degeneration. The production of inflammatory …

Omicron variant (B. 1.1. 529) challenge the integrity of blood brain barrier: Evidence from protein structural analysis

A Nasir, A Samad, S Ullah, A Ali, DQ Wei… - Computers in Biology and …, 2024 - Elsevier
Studies on nonhuman primates, wild-type and transgenic mice have shown the presence of
SARS-CoV-2 RNA components in the brains. Despite the Blood-Brain Barrier (BBB) …

The abundant distribution and duplication of SARS-CoV-2 in the cerebrum and lungs promote a high mortality rate in transgenic hACE2-C57 mice

H Li, X Zhao, S Peng, Y Li, J Li, H Zheng… - International Journal of …, 2024 - mdpi.com
Patients with COVID-19 have been reported to experience neurological complications,
although the main cause of death in these patients was determined to be lung damage …

SARS-CoV-2 variants mediated tissue-specific metabolic reprogramming determines the disease pathophysiology in a hamster model

UK Sardarni, AT Ambikan, A Acharya… - Brain, Behavior, and …, 2025 - Elsevier
Despite significant effort, a clear understanding of host tissue-specific responses and their
implications for immunopathogenicity against the severe acute respiratory syndrome …

[HTML][HTML] Long Neuro-COVID-19: Current Mechanistic Views and Therapeutic Perspectives

A Slama Schwok, J Henri - Biomolecules, 2024 - mdpi.com
Long-lasting COVID-19 (long COVID) diseases constitute a real life-changing burden for
many patients around the globe and, overall, can be considered societal and economic …

Clinical and immunological features in patients with neuroimmune complications of COVID-19 during Omicron wave in China: a case series

S Gong, B Deng, H Yu, X Zhang, W Yang… - Frontiers in …, 2024 - frontiersin.org
Purpose This study aimed to present clinical and immunological features in patients with
neuroimmune complications of COVID-19 during Omicron wave in China. Methods Patients …