Long-term and sequential treatment for osteoporosis

I Foessl, HP Dimai, B Obermayer-Pietsch - Nature Reviews …, 2023 - nature.com
Osteoporosis is a skeletal disorder that causes impairment of bone structure and strength,
leading to a progressively increased risk of fragility fractures. The global prevalence of …

Crosstalk between the gut microbiota and postmenopausal osteoporosis: Mechanisms and applications

Q Xu, D Li, J Chen, J Yang, J Yan, Y Xia… - International …, 2022 - Elsevier
Postmenopausal osteoporosis (PMO) results from a reduction in bone mass and
microarchitectural deterioration in bone tissue due to estrogen deficiency, which may …

[HTML][HTML] Harvesting phosphorus-containing moieties for their antibacterial effects

M Voráčová, M Zore, J Yli-Kauhaluoma… - Bioorganic & Medicinal …, 2023 - Elsevier
Clinically manifested resistance of bacteria to antibiotics has emerged as a global threat to
society and there is an urgent need for the development of novel classes of antibacterial …

[HTML][HTML] Bisphosphonates and dental implants: a systematic review and meta-analysis

N Sulaiman, F Fadhul, BR Chrcanovic - Materials, 2023 - mdpi.com
The purpose of the present systematic review was to investigate the influence of
bisphosphonates (BPs) on the dental implant failure rate and marginal bone loss (MBL). An …

Extensive expertise in endocrinology: Osteoporosis management

IR Reid - European journal of endocrinology, 2022 - academic.oup.com
Fractures occur in about half of older White women, and almost a third of older White men.
However, 80% of the older individuals who have fractures do not meet the bone density …

[HTML][HTML] Hydroxy-and amino-phosphonates and-bisphosphonates: Synthetic methods and their biological applications

B Kaboudin, P Daliri, S Faghih, H Esfandiari - Frontiers in Chemistry, 2022 - frontiersin.org
Phosphonates and bisphosphonates are stable analogs of phosphates and pyrophosphates
that are characterized by one and two carbon–phosphorus bonds, respectively. Among the …

A Bone‐Penetrating Precise Controllable Drug Release System Enables Localized Treatment of Osteoporotic Fracture Prevention via Modulating Osteoblast …

H Liang, K Chen, J Xie, L Yao, Y Liu, F Hu, H Li, Y Lei… - Small, 2023 - Wiley Online Library
Improving local bone mineral density (BMD) at fracture‐prone sites of bone is a clinical
concern for osteoporotic fracture prevention. In this study, a featured radial extracorporeal …

[HTML][HTML] Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine …

Y Ren, J Weeks, T Xue, J Rainbolt… - Bone research, 2023 - nature.com
Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this,
we developed bisphosphonate-conjugated sitafloxacin (BCS, BV600072) and …

[HTML][HTML] Calcium phosphate bone cements as local drug delivery systems for bone cancer treatment

A Pylostomou, Ö Demir, D Loca - Biomaterials Advances, 2023 - Elsevier
Bone cancer is usually a metastatic disease, affecting people of all ages. Its effective therapy
requires a targeted drug administration locally at the cancer site so that the surrounding …

[HTML][HTML] Targeting of mevalonate-isoprenoid pathway in acute myeloid leukemia cells by bisphosphonate drugs

E Chiarella, C Nisticò, A Di Vito, HL Morrone… - Biomedicines, 2022 - mdpi.com
Metabolic reprogramming represents a hallmark of tumorigenesis to sustain survival in
harsh conditions, rapid growth and metastasis in order to resist to cancer therapies. These …