Biomaterial-based antimicrobial therapies for the treatment of bacterial infections

PP Kalelkar, M Riddick, AJ García - Nature Reviews Materials, 2022 - nature.com
The rise in antibiotic-resistant bacteria, including strains that are resistant to last-resort
antibiotics, and the limited ability of antibiotics to eradicate biofilms have necessitated the …

Current challenges and future opportunities of phage therapy

DP Pires, AR Costa, G Pinto, L Meneses… - FEMS microbiology …, 2020 - academic.oup.com
Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …

Encapsulation and delivery of therapeutic phages

B Loh, VS Gondil, P Manohar, FM Khan… - Applied and …, 2021 - Am Soc Microbiol
Delivery of therapeutic compounds to the site of action is crucial. While many chemical
substances such as beta-lactam antibiotics can reach therapeutic levels in most parts …

Encapsulation and delivery of phage as a novel method for gut flora manipulation in situ: A review

Y Yang, H Du, G Zou, Z Song, Y Zhou, H Li… - Journal of Controlled …, 2023 - Elsevier
Intestinal flora regulation is an effective method to intervene and treat diseases associated
with microbiome imbalance. In addition to conventional probiotic supplement, phage …

In situ reprogramming of gut bacteria by oral delivery

BB Hsu, IN Plant, L Lyon, FM Anastassacos… - Nature …, 2020 - nature.com
Abundant links between the gut microbiota and human health indicate that modification of
bacterial function could be a powerful therapeutic strategy. The inaccessibility of the gut and …

Formulation strategies for bacteriophages to target intracellular bacterial pathogens

W Yan, P Banerjee, M Xu, S Mukhopadhyay… - Advanced Drug Delivery …, 2021 - Elsevier
Bacteriophages (Phages) are antibacterial viruses that are unaffected by antibiotic drug
resistance. Many Phase I and Phase II phage therapy clinical trials have shown acceptable …

Positive and negative aspects of bacteriophages and their immense role in the food chain

SA Ranveer, V Dasriya, MF Ahmad, HS Dhillon… - npj Science of …, 2024 - nature.com
Bacteriophages infect and replicate inside a bacterial host as well as serve as natural bio-
control agents. Phages were once viewed as nuisances that caused fermentation failures …

Paving the way for phage therapy using novel drug delivery approaches

T Briot, C Kolenda, T Ferry, M Medina, F Laurent… - Journal of Controlled …, 2022 - Elsevier
Bacterial resistance against antibiotics is an emergent medical issue. The development of
novel therapeutic approaches is urgently needed and, in this context, bacteriophages …

Prophylactic delivery of a bacteriophage cocktail in feed significantly reduces Salmonella colonization in pigs

AM Thanki, G Mignard, RJ Atterbury… - Microbiology …, 2022 - Am Soc Microbiol
Nontyphoidal Salmonella spp. are a leading cause of human food poisoning and can be
transmitted to humans via consuming contaminated pork. To reduce Salmonella spread to …

Microencapsulation for pharmaceutical applications: a review

C Yan, SR Kim - ACS Applied Bio Materials, 2024 - ACS Publications
In order to improve bioavailability, stability, control release, and target delivery of active
pharmaceutical ingredients (APIs), as well as to mask their bitter taste, to increase their …