The effectiveness of T-cell-mediated immunotherapy of cancer depends on both an optimal
immunostimulatory context of the therapy and the proper selection with respect to quality …

Heat shock proteins (HSPs) are primordial and abundant molecules expressed in all cells.
Publications starting in 1984 have shown that immunization of mice, rats, and frogs with …

Negative co-stimulatory signaling mediated via cell surface programmed death (PD)-1
expression modulates T and B cell activation and is involved in maintaining peripheral …

Abstract IL-17-secreting CD8 T cells (Tc17) have been described in several settings, but little
is known regarding their functional characteristics. While Tc1 cells produced IFN-γ and …

Expression of the PD-1 receptor on T cells has been shown to provide an important
inhibitory signal that down-modulates peripheral effector responses in normal tissues and …

HSV-2, the primary causative agent of genital herpes, establishes latency in sensory ganglia
and reactivates causing recurrent lesions and viral shedding. Induction or expansion of …

Innate defenses help to eliminate infection, but some of them also play a major role in
shaping the magnitude and efficacy of the adaptive immune response. With regard to …

Abstract Vaccine‐induced CD8+ T‐cell responses can eradicate developing tumors in vivo
in mouse models. Translating these successes into approved treatments for cancer patients …

Akış sitometri hücrelerin fenotipik ve karakteristik özelliklerini kalitatif ve kantitatif olarak
inceleyen bir cihazdır. Bu cihaz ile, hücrenin yüzey ve iç proteinleri, organelleri ve diğer …

Efforts to develop a subunit vaccine against genital herpes have been hampered by lack of
knowledge of the protective antigens of HSV-2, the causative agent of the disease. Vaccines …