Single‐cell RNA sequencing analysis reveals transcriptional heterogeneity of multiple primary lung cancer

W Guo, B Zhou, F Bie, Q Huai, X Xue… - Clinical and …, 2023 - Wiley Online Library
Introduction With the advancements in early diagnosis, more and more patients with multiple
primary lung cancer (MPLC) have been identified. However, the progression of MPLC …

Unraveling the tumor immune microenvironment of lung adenocarcinoma using single-cell RNA sequencing

L Song, Y Gong, E Wang… - Therapeutic Advances in …, 2024 - journals.sagepub.com
Tumor immune microenvironment (TIME) and its indications for lung cancer patient
prognosis and therapeutic response have become new hotspots in cancer research in …

Vaccine-based therapeutic interventions in lung cancer management: A recent perspective

DS Gupta, DS Gupta, NK Abjani, Y Dave, K Apte… - Medical Oncology, 2024 - Springer
The incidence of lung cancer continues to grow globally, contributing to an ever-increasing
load on healthcare systems. Emerging evidence has indicated lowered efficacy of …

The dynamic dysregulated network identifies stage-specific markers during lung adenocarcinoma malignant progression and metastasis

L Wang, W Liu, K Liu, L Wang, X Yin, L Bo, H Xu… - … Therapy-Nucleic Acids, 2022 - cell.com
Brain metastasis occurs in approximately 30% of patients with lung adenocarcinoma (LUAD)
and is closely associated with poor prognosis, recurrence, and death. However, dynamic …

Multidimensional biological characteristics of ground glass nodules

F Chen, J Li, L Li, L Tong, G Wang, X Zou - Frontiers in Oncology, 2024 - frontiersin.org
The detection rate of ground glass nodules (GGNs) has increased in recent years because
of their malignant potential but relatively indolent biological behavior; thus, correct GGN …

Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages

Y Zhao, J Gao, J Wang, F Fan, C Cheng, D Qian… - Nature …, 2024 - nature.com
Multiple synchronous lung cancers (MSLCs) constitute a unique subtype of lung cancer. To
explore the genomic and immune heterogeneity across different pathological stages of …

[HTML][HTML] Expert consensus on the multidisciplinary diagnosis and treatment of multiple ground glass nodule-like lung cancer (2024 Edition)∆

B Liu, X Ye, W Fan, X Zhi, H Ma, J Wang… - Journal of Cancer …, 2024 - journals.lww.com
This expert consensus reviews current literature and provides clinical practice guidelines for
the diagnosis and treatment of multiple ground glass nodule-like lung cancer. The main …

miR-30a-5p/PHTF2 axis regulates the tumorigenesis and metastasis of lung adenocarcinoma.

L Zhang, Q Meng, L Zhuang, Q Gong, X Huang, X Li… - …, 2024 - search.ebscohost.com
Background: Lung adenocarcinoma is a very pervasive histological form of lung cancers,
and inhibiting metastasis is crucial for effective treatment. In this investigation, we explored …

Observation on the clinical efficacy and side effects of EGFR-TKI±chemotherapy in the treatment of EGFR mutation-positive advanced lung adenocarcinoma

J Zheng, T Cui, T Li - European Journal of Inflammation, 2022 - journals.sagepub.com
Objective To assess the clinical efficacy and side effects of EGFR-TKI with or without
chemotherapy in the treatment of EGFR mutation-positive advanced lung adenocarcinoma …

Dissecting transcriptional heterogeneity in multiple primary lung cancer by single cell RNA sequencing

W Guo, H Xia, Q Huai, X Xue, L Guo, F Tan, J Zhao… - 2022 - researchsquare.com
The progression of multiple primary lung cancer (MPLC) involves complex changes in cell
composition and metabolic function. Here, we performed scRNA sequencing of 167,397 …