The potent actions of pigment epithelium-derived factor (PEDF) on tumour-associated cells,
and its extracellular localization and secretion, stimulated research on this multifunctional …

Microvascular diseases are among the most clinically important diseases, and vascular
abnormalities are central in the development of such diseases. Pigment epithelium-derived …

Diabetic foot ulcer (DFU) caused by impaired wound healing is a common vascular
complication of diabetes. The current study revealed that plasma levels of pigment …

There is growing evidence that the p53 tumour suppressor downregulates vascular
endothelial growth factor (VEGF) expression, although the underlying mechanisms remain …

Purpose.: Without therapeutic intervention, corneal neovascularization rapidly compromises
visual acuity, and is a leading cause of blindness. Artesunate was reported to inhibit …

To reduce the side effects and improve the lack of clinical treatment countermeasures in
endometriosis chemotherapy, a polymeric micelle gene delivery system composed of lipid …

Retinoblastoma is the most common intraocular malignancy in children with poor prognosis.
The progression of retinoblastoma is dependent on a robust angiogenic response. Targeting …

Both elevated plasma free fatty acids (FFA) and accumulating triglyceride in adipose tissue
are observed in the process of obesity and insulin resistance. This contradictory …

Sorafenib, a small-molecule tyrosine kinase inhibitor with antiangiogenic activity, has been
used in liver cancer and kidney cancer treatments. However, clinical trials with sorafenib for …

Background & Aims Post-hepatectomy liver failure (PHLF) leads to poor prognosis in
patients undergoing hepatectomy, with hepatic vascular reconstitution playing a critical role …