Fibrous scaffolds for building hearts and heart parts
Extracellular matrix (ECM) structure and biochemistry provide cell-instructive cues that
promote and regulate tissue growth, function, and repair. From a structural perspective, the …
promote and regulate tissue growth, function, and repair. From a structural perspective, the …
Advances in computational modelling for personalised medicine after myocardial infarction
Myocardial infarction (MI) is a leading cause of premature morbidity and mortality worldwide.
Determining which patients will experience heart failure and sudden cardiac death after an …
Determining which patients will experience heart failure and sudden cardiac death after an …
[HTML][HTML] 3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics
Two crucial factors for accurate numerical simulations of cardiac electromechanics, which
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …
Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments
Ventricular wall stress is believed to be responsible for many physical mechanisms taking
place in the human heart, including ventricular remodeling, which is frequently associated …
place in the human heart, including ventricular remodeling, which is frequently associated …
MRI evaluation of injectable hyaluronic acid-based hydrogel therapy to limit ventricular remodeling after myocardial infarction
SM Dorsey, JR McGarvey, H Wang, A Nikou, L Arama… - Biomaterials, 2015 - Elsevier
Injectable biomaterials are an attractive therapy to attenuate left ventricular (LV) remodeling
after myocardial infarction (MI). Although studies have shown that injectable hydrogels …
after myocardial infarction (MI). Although studies have shown that injectable hydrogels …
A myocardial infarct border-zone-on-a-chip demonstrates distinct regulation of cardiac tissue function by an oxygen gradient
After a myocardial infarction, the boundary between the injured, hypoxic tissue and the
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …
Construction and validation of subject-specific biventricular finite-element models of healthy and failing swine hearts from high-resolution DT-MRI
Predictive computational modeling has revolutionized classical engineering disciplines and
is in the process of transforming cardiovascular research. This is particularly relevant for …
is in the process of transforming cardiovascular research. This is particularly relevant for …
Changes and classification in myocardial contractile function in the left ventricle following acute myocardial infarction
In this research, we hypothesized that novel biomechanical parameters are discriminative in
patients following acute ST-segment elevation myocardial infarction (STEMI). To identify …
patients following acute ST-segment elevation myocardial infarction (STEMI). To identify …
The impact of myocardial compressibility on organ-level simulations of the normal and infarcted heart
Myocardial infarction (MI) rapidly impairs cardiac contractile function and instigates
maladaptive remodeling leading to heart failure. Patient-specific models are a maturing …
maladaptive remodeling leading to heart failure. Patient-specific models are a maturing …
Image-based predictive modeling of heart mechanics
Personalized biophysical modeling of the heart is a useful approach for noninvasively
analyzing and predicting in vivo cardiac mechanics. Three main developments support this …
analyzing and predicting in vivo cardiac mechanics. Three main developments support this …