Receptor for advanced glycation end-products (RAGE) is a member of the immunoglobulin
superfamily. RAGE binds and mediates cellular responses to a range of DAMPs (damage …

Advanced glycation end products (AGEs) are a diverse range of compounds that are formed
when free amino groups of proteins, lipids, and nucleic acids are carbonylated by reactive …

High-mobility Group Box 1 (HMGB1) is a nuclear protein that plays a key role in acute and
chronic inflammation. It has already been studied in several diseases, among them …

Receptor for advanced glycation end products (RAGE) is an immunoglobulin-like receptor
present on cell surface. RAGE binds to an array of structurally diverse ligands, acts as a …

Mitochondrial function is essential for bioenergetics, metabolism, and signaling and is
compromised in diseases such as proteinuric kidney diseases, contributing to the global …

S100 proteins are members of the superfamily of Ca 2+-binding proteins characterized by
the specific Ca 2+-binding motif, the EF-hand. Proteins of this superfamily are of clinical use …

Despite recent progresses in its treatment, malignant cutaneous melanoma remains a
cancer with very poor prognosis. Emerging evidences suggest that the receptor for advance …

Microglia are intrinsic immune cells of the central nervous system and play a dual role (pro-
inflammatory and anti-inflammatory) in the homeostasis of the nervous system …

A multitude of Ca 2+-sensor proteins containing the specific Ca 2+-binding motif (helix-loop-
helix, called EF-hand) are of major clinical relevance in a many human diseases …

Neurodegenerative diseases constitute a broad category of diseases caused by the
degeneration of the neurons. They are mainly manifested by the gradual loss of neuron …