Necroptosis is a caspase-independent, lytic form of programmed cell death whose errant
activation has been widely implicated in many pathologies. The pathway relies on the …

The death of endocrine cells is involved in type 1 diabetes mellitus, autoimmunity,
adrenopause and hypogonadotropism. Insights from research on basic cell death have …

The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However,
the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in …

Phosphorylation of the MLKL pseudokinase by the RIPK3 kinase leads to MLKL
oligomerization, translocation to, and permeabilization of, the plasma membrane to induce …

Necroptosis is a regulated caspase-independent form of necrotic cell death that results in an
inflammatory phenotype. This process contributes profoundly to the pathophysiology of …

Protein kinases are present in all domains of life and play diverse roles in cellular signaling.
Whereas the impact of substrate phosphorylation by protein kinases has long been …

Mixed Lineage Kinase domain-Like pseudokinase (MLKL) is implicated in a broad range of
diseases due to its role as the ultimate effector of necroptosis and has therefore emerged as …

The receptor-interacting serine/threonine protein kinase 1 (RIPK1) is a key mediator of
regulated cell death and inflammation. Recent studies suggest that RIPK1 inhibition would …

The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely
implicated in human disease, including renal, pulmonary, gut and skin inflammatory …

As a serine/threonine protein kinase, receptor-interacting protein 1 (RIP1) plays an important
role in regulating the pathways in programmed cell death. Multifaceted human diseases (eg …