Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of
patients with chronic liver disease. Their prevention or reversal have become major …

Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors that
are members of the receptor tyrosine kinase family. Both DDRs bind a number of different …

Almost all human cancers display dysregulated expression and/or function of one or more
receptor tyrosine kinases (RTKs). The strong causative association between altered RTK …

Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

Chronic liver injury due to viral hepatitis, alcohol abuse, and metabolic disorders is a
worldwide health concern. Insufficient treatment of chronic liver injury leads to fibrosis …

Organ fibrosis is a pathological condition associated with chronic inflammatory diseases. In
fibrosis, excessive deposition of extracellular matrix (ECM) severely impairs tissue …

Discoidin domain receptors, DDR1 and DDR2, lie at the intersection of two large receptor
families, namely the extracellular matrix and tyrosine kinase receptors. As such, DDRs are …

Over the last two decades, our understanding of the pathological role of hepatic stellate cells
(HSCs) in fibrotic liver disease has increased dramatically. As HSCs are identified as the …

Liver fibrosis is an excessive production, aberrant deposition, and deficit degradation of
extracellular matrix (ECM). Patients with unresolved fibrosis ultimately undergo end-stage …