Abstract Information theory has long been used to quantify interactions between two
variables. With the rise of complex systems research, multivariate information measures …

Brain functions are strictly dependent on neural connections formed during development
and modified during life. The cellular and molecular mechanisms underlying …

The brain's extracellular matrix (ECM) is a macromolecular network composed of
glycosaminoglycans, proteoglycans, glycoproteins, and fibrous proteins. In vitro studies …

Dissociated cortical neurons from rat embryos cultured onto micro-electrode arrays exhibit
characteristic patterns of electrophysiological activity, ranging from isolated spikes in the first …

A major goal of neuroscience is understanding how neurons arrange themselves into neural
networks that result in behavior. Most theoretical and experimental efforts have focused on a …

For the last century, many neuroscientists around the world have dedicated their lives to
understanding how neuronal networks work and why they stop working in various diseases …

The study of electrical network systems, integrated with chemical signaling networks, is
becoming a common trend in contemporary biology. Classical techniques are limited to the …

The production of functional human embryonic stem cell (hESC)-derived neuronal cells is
critical for the application of hESCs in treating neurodegenerative disorders. To study the …

Bursts of action potentials within neurons and throughout networks are believed to serve
roles in how neurons handle and store information, both in vivo and in vitro. Accurate …

To investigate distributed synaptic plasticity at the cell assembly level, we used dissociated
cortical networks from embryonic rats grown on grids of 60 extracellular substrate …