The development of responsive biomaterials capable of demonstrating modulated function
in response to dynamic physiological and mechanical changes in vivo remains an important …

This review focuses on current tissue engineering strategies for promoting vascularized
bone regeneration. We review the role of angiogenic growth factors in promoting …

Biomaterials developed to treat bone defects have classically focused on bone healing via
direct, intramembranous ossification. In contrast, most bones in our body develop from a …

Successful osteochondral defect repair requires regenerating the subchondral bone whilst
simultaneously promoting the development of an overlying layer of articular cartilage that is …

The natural process of endochondral bone formation in the growing skeletal system is
increasingly inspiring the field of bone tissue engineering. However, in order to create …

Background Bone grafts are required to repair large bone defects after tumour resection or
large trauma. The availability of patients' own bone tissue that can be used for these …

Despite its natural healing potential, bone is unable to regenerate sufficient tissue within
critical‐sized defects, resulting in a non‐union of bone ends. As a consequence …

There is an urgent, clinical need for an alternative to the use of autologous grafts for the ever
increasing number of bone grafting procedures performed annually. Herein, we describe a …

Mesenchymal stem cells (MSCs) are multipotent cells capable of proliferating and
differentiating into several lineages. In regenerative medicine, their potential as a resource …

Biogenic bioceramics scaffolds are receiving considerable attention for bone restoration
applications. Compared with scaffolds of chemical origin, biogenic scaffolds exhibit greater …