Immune checkpoint inhibitors (ICIs) are a novel class of immunotherapy drugs that have
improved the treatment of a broad spectrum of cancers as metastatic melanoma, non-small …

Individuals age> 65 years old are the fastest expanding population demographic throughout
the developed world. Consequently, more aged patients than before are receiving …

The ability of the kidney to regenerate successfully after injury is lost with advancing age,
chronic kidney disease, and after irradiation. The factors responsible for this reduced …

Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Cellular senescence is a major contributor to age-related diseases in humans; however, it
also has a beneficial role in physiological and pathological processes, including wound …

Persistent low-grade inflammation and premature ageing are hallmarks of the uremic
phenotype and contribute to impaired health status, reduced quality of life, and premature …

The senescence programme is implicated in diverse biological processes, including
embryogenesis, tissue regeneration and repair, tumorigenesis, and ageing. Although in vivo …

Senescent cells have undergone permanent growth arrest, adopt an altered secretory
phenotype, and accumulate in the kidney and other organs with ageing and injury …

Fibrosis is responsible for chronic progressive kidney failure, which is present in a large
number of adults in the developed world. It is increasingly appreciated that acute kidney …

Aging is a biological feature that is characterized by gradual degeneration of function in
cells, tissues, organs, or an intact organism due to the accumulation of environmental factors …