TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human
cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 …

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

Forty years of research have established that the p53 tumor suppressor provides a major
barrier to neoplastic transformation and tumor progression by its unique ability to act as an …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

Abstract p53 is a key tumor suppressor, and loss of p53 function is frequently a prerequisite
for cancer development. The p53 gene is the most frequently mutated gene in human …

TP53 is the most frequently mutated tumor suppressor gene in human cancer. The majority
of mutations of p53 are missense mutations, leading to the expression of the full length p53 …

Apoptosis is a form of programmed cell death that is mediated by intrinsic and extrinsic
pathways. Dysregulation of and resistance to cell death are hallmarks of cancer. For over …