After the storm: regeneration, repair, and reestablishment of homeostasis between the alveolar epithelium and innate immune system following viral lung injury

JD Planer, EE Morrisey - Annual Review of Pathology …, 2023 - annualreviews.org
The mammalian lung has an enormous environmental-epithelial interface that is optimized
to accomplish the principal function of the respiratory system, gas exchange. One …

Delineating COVID-19 immunological features using single-cell RNA sequencing

W Liu, J Jia, Y Dai, W Chen, G Pei, Q Yan, Z Zhao - The Innovation, 2022 - cell.com
Understanding the molecular mechanisms of coronavirus disease 2019 (COVID-19)
pathogenesis and immune response is vital for developing therapies. Single-cell RNA …

Hamster model for post-COVID-19 alveolar regeneration offers an opportunity to understand post-acute sequelae of SARS-CoV-2

L Heydemann, M Ciurkiewicz, G Beythien… - Nature …, 2023 - nature.com
COVID-19 survivors often suffer from post-acute sequelae of SARS-CoV-2 infection (PASC).
Current evidence suggests dysregulated alveolar regeneration as a possible explanation for …

ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury

AI Weiner, G Zhao, HM Zayas, NP Holcomb… - Cell reports, 2022 - cell.com
The lung exhibits a robust, multifaceted regenerative response to severe injuries such as
influenza infection, during which quiescent lung-resident epithelial progenitors participate in …

[HTML][HTML] Lung remodeling regions in long-term coronavirus disease 2019 feature basal epithelial cell reprogramming

K Wu, Y Zhang, SR Austin, H Yin-Declue… - The American Journal of …, 2023 - Elsevier
Respiratory viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), can trigger chronic lung disease that persists and even progresses after expected …

A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response

SL Leibel, RN McVicar, R Murad, EM Kwong… - Proceedings of the …, 2024 - pnas.org
The prevalence of “long COVID” is just one of the conundrums highlighting how little we
know about the lung's response to viral infection, particularly to syndromecoronavirus-2 …

Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells

SM Pinto, Y Subbannayya, H Kim, L Hagen, MW Górna… - IScience, 2023 - cell.com
COVID-19 pandemic continues to remain a global health concern owing to the emergence
of newer variants. Several multi-Omics studies have produced extensive evidence on host …

Lactobacillus rhamnosus Restores Antiviral Signaling and Attenuates Cytokines Secretion from Human Bronchial Epithelial Cells Exposed to Cigarette Smoke and …

F Olímpio, R Andreata-Santos, PC Rosa… - Probiotics and …, 2023 - Springer
Individuals with chronic obstructive pulmonary disease (COPD) are more susceptible to
exacerbation crisis triggered by secondary lung infections due to the dysfunction of antiviral …

Alveolar regeneration in COVID-19 patients: a network perspective

SK Gupta, M Srivastava, R Minocha, A Akash… - International Journal of …, 2021 - mdpi.com
A viral infection involves entry and replication of viral nucleic acid in a host organism,
subsequently leading to biochemical and structural alterations in the host cell. In the case of …

Development of single-cell transcriptomics and its application in COVID-19

C Wang, T Huyan, X Zhou, X Zhang, S Duan, S Gao… - Viruses, 2022 - mdpi.com
Over the last three years, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2)-related health crisis has claimed over six million lives and caused USD 12 trillion losses …