Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

Proliferating cells exhibit a metabolic phenotype known as" aerobic glycolysis," which is
characterized by an elevated rate of glucose fermentation to lactate irrespective of oxygen …

Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …

A long-standing question in cancer biology has been why oxygenated tumors ferment the
majority of glucose they consume to lactate rather than oxidizing it in their mitochondria, a …

Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite
available oxygen, is associated with proliferation across many organisms and conditions. To …

Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Mitofusins reside on the outer mitochondrial membrane and regulate mitochondrial fusion, a
physiological process that impacts diverse cellular processes. Mitofusins are activated by …

Metabolic reprogramming is a key feature of many cancers, but how and when it contributes
to tumorigenesis remains unclear. Here we demonstrate that metabolic reprogramming …

Mitochondria are important regulators of macrophage polarisation. Here, we show that
arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein …