How to fix DNA breaks: new insights into the mechanism of non-homologous end joining
A Vogt, Y He, SP Lees-Miller - Biochemical Society Transactions, 2023 - portlandpress.com
Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation-
induced DNA double-strand breaks (DSBs) in human cells and is essential for the …
induced DNA double-strand breaks (DSBs) in human cells and is essential for the …
Small molecule ATM inhibitors as potential cancer therapy: a patent review (2003–present)
YA Ivanenkov, AS Malyshev, AS Malyshev… - Expert Opinion on …, 2025 - Taylor & Francis
Introduction The ataxia telangiectasia mutated kinase (ATM) is key in coordinating the DDR
signaling network essential for responding to double-strand breaks (DSBs). Several ATM …
signaling network essential for responding to double-strand breaks (DSBs). Several ATM …
Persistent hypertension induces atrial remodeling and atrial fibrillation through DNA damage and ATM/CHK2/p53 signaling pathway
Y Huang, J Zhao, Z Zhou, X Guo, Y Xu, T Huang… - … et Biophysica Acta (BBA …, 2025 - Elsevier
Atrial fibrillation (AF) is the most prevalent arrhythmia in clinical practice, with hypertension
emerging as an independent risk factor. Previous literature has established associations …
emerging as an independent risk factor. Previous literature has established associations …
An ATM D-compartmentalization in DNA damage response
A Prasad, A Kanakkanthara - Trends in Cell Biology, 2024 - cell.com
How chromatin configuration impacts DNA repair is an emerging question. A recent study by
Arnould et al. shows that ATM orchestrates a new chromatin compartment (D compartment) …
Arnould et al. shows that ATM orchestrates a new chromatin compartment (D compartment) …
[HTML][HTML] Integrated omics analysis unveils a DNA damage response to neurogenic injury
AH Gheinani, BS Sack, A Bigger-Allen, H Thaker… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) evokes profound bladder dysfunction. Current treatments are limited
by a lack of molecular data to inform novel therapeutic avenues. Previously, we showed …
by a lack of molecular data to inform novel therapeutic avenues. Previously, we showed …
A miR-100 Polymorphism Signature is Protectively Associated with Hematological Abnormalities in Individuals Exposed to Benzene, Toluene, Ethylbenzene, and …
FN Dehkordi, SJ Roshan, A Yousefvand… - Biomedical and …, 2024 - besjournal.com
Objective The DNA double-strand break (DSB) repair system plays a key role in eliminating
DNA damage in hematopoietic cells caused by benzene, toluene, ethylbenzene, and xylene …
DNA damage in hematopoietic cells caused by benzene, toluene, ethylbenzene, and xylene …
Interakce virů s buněčnými mechanismy oprav poškozené DNA
E Lemberková - 2024 - dspace.cuni.cz
Pro každou buňku je zásadní zachovávat si integritu své genomové DNA. Integrita genomu
je narušována vnějšími a vnitřními vlivy, které působí na buňku a poškozují její genetickou …
je narušována vnějšími a vnitřními vlivy, které působí na buňku a poškozují její genetickou …