Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

During ontogeny, proliferating cells become restricted in their fate through the combined
action of cell-type-specific transcription factors and ubiquitous epigenetic machinery, which …

After fertilization, to initiate development, gametes are reprogramed to become totipotent.
Approximately half of the mammalian genome consists of repetitive elements, including …

DNA methylation (DNAme) is an important epigenetic mark in diverse species. Our current
understanding of DNAme is based on measurements from bulk cell samples, which …

Epigenetic modifications established during gametogenesis regulate transcription and other
nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal …

The histone variant H3. 3 is enriched at enhancers and active genes, as well as repeat
regions such as telomeres and retroelements, in mouse embryonic stem cells (mESCs) …

Histone 3 K4 trimethylation (depositing H3K4me3 marks) is typically associated with active
promoters yet paradoxically occurs at untranscribed domains. Research to delineate the …

Proper follicle development is very important for the production of mature oocytes, which is
essential for the maintenance of female fertility. This complex biological process requires …

Epigenetic information in the mammalian oocyte has the potential to be transmitted to the
next generation and influence gene expression; this occurs naturally in the case of imprinted …