The emergence of drug resistance is a major challenge for oncologists. Resistance can be
categorized as acquired or intrinsic; the alteration of several biological mechanisms …

Cancer is one of the most frequently diagnosed malignant diseases worldwide, posing a
serious, long-term threat to patients' health and life. Systemic chemotherapy remains the first …

Aims This study aims at investigating the role of a neighbor long non-coding RNA (lncRNA)
of HDAC4 (LOC85009) in docetaxel (DTX) resistance of lung adenocarcinoma (LUAD) …

Autophagy is a conserved process in which the cytosolic materials are degraded and
eventually recycled for cellular metabolism to maintain homeostasis. The dichotomous role …

Idiopathic pulmonary fibrosis (IPF) is characterized by lung scarring and has no effective
treatment. Fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and …

Abstract Abnormal 5-methylcytosine (m5C) methylation has been proved to be closely
related to gastric carcinogenesis, progression, and prognosis. Dysregulated long noncoding …

Cancer immunotherapy is a promising antitumor approach, whereas nontherapeutic side
effects, tumor microenvironment (TME) intricacy, and low tumor immunogenicity limit its …

Sunitinib resistance remains a serious challenge to the treatment of advanced and
metastatic renal cell carcinoma (RCC), yet the mechanisms underlying this resistance are …

Cumulative studies have shown that many long non-coding RNAs (lncRNAs) are crucial in a
number of diseases. Predicting potential lncRNA-disease associations (LDAs) can facilitate …

Macroautophagy/autophagy is a highly conserved evolutionary mechanism that involves
lysosomes for the degradation of cytoplasmic components including organelles. The …