Alternative renin-angiotensin system
M Bader, UM Steckelings, N Alenina, RAS Santos… - …, 2024 - Am Heart Assoc
The renin-angiotensin system is the most important peptide hormone system in the
regulation of cardiovascular homeostasis. Its classical arm consists of the enzymes, renin …
regulation of cardiovascular homeostasis. Its classical arm consists of the enzymes, renin …
Genetic Code Expansion: Recent Developments and Emerging Applications
Y Huang, P Zhang, H Wang, Y Chen, T Liu… - Chemical …, 2024 - ACS Publications
The concept of genetic code expansion (GCE) has revolutionized the field of chemical and
synthetic biology, enabling the site-specific incorporation of noncanonical amino acids …
synthetic biology, enabling the site-specific incorporation of noncanonical amino acids …
Host heparan sulfate promotes ACE2 super-cluster assembly and enhances SARS-CoV-2-associated syncytium formation
SARS-CoV-2 infection causes spike-dependent fusion of infected cells with ACE2 positive
neighboring cells, generating multi-nuclear syncytia that are often associated with severe …
neighboring cells, generating multi-nuclear syncytia that are often associated with severe …
Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1
SARS-CoV-2 and filovirus enter cells via the cell surface angiotensin-converting enzyme 2
(ACE2) or the late-endosome Niemann-Pick C1 (NPC1) as a receptor. Here, we screened …
(ACE2) or the late-endosome Niemann-Pick C1 (NPC1) as a receptor. Here, we screened …
Facilitating and restraining virus infection using cell-attachable soluble viral receptors
H Zhang, Z Wang, HTT Nguyen… - Proceedings of the …, 2024 - pnas.org
SARS-CoV-2 uses the receptor binding domain (RBD) of its spike protein to recognize and
infect host cells by binding to the cell surface receptor angiotensin converting enzyme 2 …
infect host cells by binding to the cell surface receptor angiotensin converting enzyme 2 …
Re-Engineered Pseudoviruses for Precise and Robust 3D Mapping of Viral Infection
Engineered vesicular stomatitis virus (VSV) pseudotyping offers an essential method for
exploring virus–cell interactions, particularly for viruses that require high biosafety levels …
exploring virus–cell interactions, particularly for viruses that require high biosafety levels …
[HTML][HTML] Site-specific protein labeling strategies for super-resolution microscopy
Super-resolution microscopy (SRM) has transformed our understanding of proteins'
subcellular organization and revealed cellular details down to nanometers, far beyond …
subcellular organization and revealed cellular details down to nanometers, far beyond …
Synergistic Binding of SARS-CoV-2 to ACE2 and Gangliosides in Native Lipid Membranes
M Dey, A Sharma, G Dhanawat, D Gupta… - ACS Infectious …, 2024 - ACS Publications
Viruses utilize cell surface glycans and plasma membrane receptors to attain an adequate
attachment strength for initiating cellular entry. We show that SARS-CoV-2 particles bind to …
attachment strength for initiating cellular entry. We show that SARS-CoV-2 particles bind to …
Giant Plasma Membrane Vesicles as Cellular‐Mimics for Probing SARS‐CoV‐2 Binding at Single Particle Level
M Dey, G Dhanawat, D Gupta, A Goel… - …, 2023 - Wiley Online Library
Membrane receptors, attachment factors and various other membrane factors play a critical
role in the specific attachment of virus particles to a cell surface. Researchers have been …
role in the specific attachment of virus particles to a cell surface. Researchers have been …
The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane
Abstract Background The Niemann Pick C1 (NPC1) protein is an intracellular cholesterol
transporter located in the late endosome/lysosome (LE/Ly) that is involved in the …
transporter located in the late endosome/lysosome (LE/Ly) that is involved in the …