Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

Efficient inflammation resolution is important not only for the termination of the inflammatory
response but also for the restoration of tissue integrity. An integral process to resolution of …

Although critical for host defense, innate immune cells are also pathologic drivers of acute
respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus …

Neutrophils dominate the early immune response in pathogen-induced acute lung injury, but
efforts to harness their responses have not led to therapeutic advancements. Neutrophil …

The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue
homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and …

Non-alcoholic fatty liver disease—the most common chronic liver disease—encompasses a
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …

Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …

Infections, cardiovascular disease, and cancer are major causes of disease and death
worldwide. Neutrophils are inescapably associated with each of these health concerns, by …

Resolution of inflammation is a coordinated and active process aimed at restoration of tissue
integrity and function. This review integrates the key molecular and cellular mechanisms of …

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are
characterised by aberrant immunological responses leading to chronic inflammation without …