Chemotherapy-induced peripheral neuropathy (CIPN) is a serious and often persistent
adverse consequence of certain chemotherapeutic agents. It is a major dose-limiting factor …

SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 recepto... : PAIN SARS-CoV-2 spike
protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia : PAIN …

The loss of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SN)
underlies the core motor symptoms of the progressive movement disorder Parkinson's …

Transmembrane Cav2. 2 (N-type) voltage-gated calcium channels are genetically and
pharmacologically validated, clinically relevant pain targets. Clinical block of Cav2. 2 (eg …

Neuropathic pain caused by lesions to somatosensory neurons due to injury or disease is a
widespread public health problem that is inadequately managed by small-molecule …

Ca2+ influx through high-voltage-activated calcium channels (HVACCs) controls diverse
cellular functions. A critical feature enabling a singular signal, Ca2+ influx, to mediate …

Abstract Neuropilin-1 (NRP-1) is a transmembrane glycoprotein that binds numerous
ligands including vascular endothelial growth factor A (VEGFA). Binding of this ligand to …

Noxious stimuli like cold, heat, pH change, tissue damage, and inflammation depolarize a
membrane of peripheral endings of specialized nociceptive neurons which eventually …

Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the
discovery of their relation to pain processing control, they are investigated to find new …

Inhibiting high-voltage-activated calcium channels (HVACCs; CaV1/CaV2) is therapeutic for
myriad cardiovascular and neurological diseases. For particular applications, genetically …