Hypertension is the leading cause of morbidity and mortality globally among all
cardiovascular diseases. Purinergic signalling plays a crucial role in hypertension through …

Proper renal blood flow (RBF) and glomerular filtration rate (GFR) are critical for maintaining
normal blood pressure, kidney function and water and electrolyte homeostasis. The renal …

Background The pathogenesis of hypertension is distinct between men and women.
Endothelin-1 (ET-1) is a potential contributor to sex differences in the pathophysiology of …

Aim Little is known about how toll‐like receptor 4 (TLR 4) influences the renal
microvasculature. We hypothesized that acute TLR 4 stimulation with lipopolysaccharide …

Objective: Although it is known that there are changes in the vascular purinergic system in
diabetes, it is unknown whether P2X1-mediated vascular responses are affected. In this …

Background: Hypertension is one of the most serious cardiovascular diseases due to its end
organ complications on the heart, kidney, and brain. Hydrogen sulfide gas was shown to be …

Toll-like receptor 4 (TLR4) activation contributes to vascular dysfunction in pathological
conditions such as hypertension and diabetes, but the role of chronic TLR4 activation on …

Renal autoregulation is an intrinsic property of afferent arterioles that maintains a stable
RBF, glomerular capillary pressure, and GFR, while protecting the glomeruli against …