Doxorubicin (DOX) is an effective antineoplastic agent used to treat various types of cancers.
However, its use is limited by the development of cardiotoxicity, which may result in heart …

There is an increased prevalence of cancer, and chemotherapy is widely and routinely
utilized to manage the majority of cancers; however, administration of chemotherapeutic …

Simple Summary This study investigated how different doses of the chemotherapeutic drug
doxorubicin affected physiological parameters and autonomic function in rats. A positive …

Doxorubicin (DXR) is widely used in cancer treatment. However, it has not yet been possible
to prevent the side effects of DXR. The aim of this study was to investigate the …

Doxorubicin is widely used for the treatment of human cancer, but its clinical use is limited by
a cumulative dose-dependent cardiotoxicity. However, the mechanism of doxorubicin …

The substance P (SP) and neurokinin-1 receptor (NK-1R) axis is crucial in numerous
pathological processes, including inflammation, stress responses, pain perception, and …

Doxorubicin has been used extensively as a potent anticancer agent, but its clinical use is
limited by its cardiotoxicity. However, the underlying mechanisms remain to be fully …

Aim With the advancement of anti-cancer medicine, cardiovascular toxicities due to cancer
therapies are common in oncology patients, resulting in increased mortality and economic …

Objectives: Cardiotoxic chemotherapy is used to treat malignancies such as breast cancer
and lymphoma. These treatments predispose patients to cardiotoxicity that can lead to …

Results Nox2 deficiency improves survival rate and prevents cardiac atrophy and LV
dysfunction in doxorubicin‑induced cardiomyopathy During the 1-week period after …