Lessons from the host defences of bats, a unique viral reservoir
There have been several major outbreaks of emerging viral diseases, including Hendra,
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …
[HTML][HTML] The world goes bats: living longer and tolerating viruses
For centuries, people believed that bats possessed sinister powers. Bats are thought to be
ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most …
ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most …
[HTML][HTML] Isolation, sequence, infectivity, and replication kinetics of severe acute respiratory syndrome coronavirus 2
A Banerjee, JA Nasir, P Budylowski, L Yip… - Emerging infectious …, 2020 - ncbi.nlm.nih.gov
Since its emergence in Wuhan, China, in December 2019, severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has infected≈ 6 million persons worldwide. As …
syndrome coronavirus 2 (SARS-CoV-2) has infected≈ 6 million persons worldwide. As …
Alternative animal models of aging research
S Holtze, E Gorshkova, S Braude… - Frontiers in Molecular …, 2021 - frontiersin.org
Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …
COVID-19 in immunosuppressed children
E Nicastro, L Verdoni, LR Bettini, G Zuin… - Frontiers in …, 2021 - frontiersin.org
Following the spread of the SARS-CoV-2 infection and coronavirus disease 2019 (COVID-
19) to a global pandemic, concerns have arisen for the disease impact in at-risk populations …
19) to a global pandemic, concerns have arisen for the disease impact in at-risk populations …
Antiviral effects of interferon-stimulated genes in bats
D Zhang, AT Irving - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
The interferon pathway is the first line of defense in viral infection in all mammals, and its
induction stimulates broad expression of interferon-stimulated genes (ISGs). In mice and …
induction stimulates broad expression of interferon-stimulated genes (ISGs). In mice and …
Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses
Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies
have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data …
have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data …
Fundamental characteristics of bat interferon systems
E Clayton, M Munir - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Interferons are an essential component of the innate arm of the immune system and are
arguably one of the most important lines of defence against viruses. The human IFN system …
arguably one of the most important lines of defence against viruses. The human IFN system …
RTP4 is a potent IFN-inducible anti-flavivirus effector engaged in a host-virus arms race in bats and other mammals
Among mammals, bats are particularly rich in zoonotic viruses, including flaviviruses.
Certain bat species can be productively yet asymptomatically infected with viruses that …
Certain bat species can be productively yet asymptomatically infected with viruses that …
Disease tolerance as immune defense strategy in bats: One size fits all?
G Pei, A Balkema-Buschmann, A Dorhoi - Plos Pathogens, 2024 - journals.plos.org
Bats are natural reservoirs for zoonotic pathogens, yet the determinants of microbial
persistence as well as the specific functionality of their immune system remain largely …
persistence as well as the specific functionality of their immune system remain largely …