Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by
cognitive dysfunction and synaptic failure. The current therapeutic approaches are mainly …

The constant dynamic movement of synapses and their components has emerged in the last
decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein …

Microglia maintain homeostasis in the brain, but whether aberrant microglial activation can
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …

Circular RNAs (circRNAs) have re-emerged as an interesting RNA species. Using deep
RNA profiling in different mouse tissues, we observed that circRNAs were substantially …

Human neuroimaging studies suggest that aberrant neural connectivity underlies
behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural …

The postsynaptic side of the synapse is specialized to receive the neurotransmitter signal
released from the presynaptic terminal and transduce it into electrical and biochemical …

Excitatory (glutamatergic) synapses in the mammalian brain are usually situated on dendritic
spines, a postsynaptic microcompartment that also harbors organelles involved in protein …

Dendritic spines, the tiny protrusions that stud the surface of many neurons, are the location
of over 90% of all excitatory synapses that occur in the CNS. Their small size has, in large …

In CNS synapses, the synaptic junctional complex with associated postsynaptic density is
presumed to contain proteins responsible for adhesion between pre-and postsynaptic …

The postsynaptic density is a highly dynamic structure, which is reorganized in an activity-
dependent manner. An animal model for temporal lobe epilepsy, ie kainate-induced limbic …