Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …

Cell growth (an increase in cell mass and size through macromolecular biosynthesis) and
cell cycle progression are generally tightly coupled, allowing cells to proliferate continuously …

Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown
mechanisms,. The roles of two signalling pathways implicated in muscle hypertrophy on the …

The present study identifies the operation of a signal tranduction pathway in mammalian
cells that provides a checkpoint control, linking amino acid sufficiency to the control of …

High-resistance exercise training results in an increase in muscle wet mass and protein
content. To begin to address the acute changes following a single bout of high-resistance …

The mammalian target of rapamycin complex 1 (mTORC1) is a critical regulator of protein
synthesis. The best studied targets of mTORC1 in translation are the eukaryotic initiation …

The mammalian target of rapamycin (mTOR) integrates nutrient and mitogen signals to
regulate cell growth (increased cell mass and cell size) and cell division. The …

Regulation of protein synthesis in eukaryotes plays a critical role in development,
differentiation, cell cycle progression, cell growth, and apoptosis (Mathews et al. 2000) …

Rapamycin, a macrocyclic lactone, is a highly specific inhibitor of the serine/threonine
protein kinase target of rapamycin (TOR). Although it is clear that TOR controls initiation of …

Ribosome biogenesis and translation control are essential cellular processes that are
governed at numerous levels. Several tumour suppressors and proto-oncogenes have been …