Opportunities for improved clinical trial designs in acute respiratory distress syndrome

KD Wick, NR Aggarwal, MAQ Curley… - The Lancet …, 2022 - thelancet.com
The acute respiratory distress syndrome (ARDS) is a common critical illness syndrome with
high morbidity and mortality. There are no proven pharmacological therapies for ARDS. The …

First stabilize and then gradually recruit: a paradigm shift in protective mechanical ventilation for acute lung injury

GF Nieman, DW Kaczka, PL Andrews, A Ghosh… - Journal of clinical …, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) is associated with a heterogeneous pattern of
injury throughout the lung parenchyma that alters regional alveolar opening and collapse …

Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: a retrospective analysis

Y Lu, H Guo, X Chen, Q Zhang - Plos one, 2021 - journals.plos.org
Previous studies have shown that lactate/albumin ratio (LAR) can be used as a prognostic
biomarker to independently predict the mortality of sepsis and severe heart failure. However …

Macrophage-targeted nanomedicines for ARDS/ALI: Promise and potential

R Vichare, JM Janjic - Inflammation, 2022 - Springer
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by
progressive lung impairment typically triggered by inflammatory processes. The mortality toll …

Inhaled CD24-enriched exosomes (EXO-CD24) as a novel immune modulator in respiratory disease

S Shapira, R Schwartz, S Tsiodras, A Bar-Shai… - International Journal of …, 2023 - mdpi.com
Acute Respiratory Distress Syndrome (ARDS) is a major health concern with urgent unmet
need for treatment options. There are three million new ARDS cases annually, and the …

Association between patient race and ethnicity and use of invasive ventilation in the United States

FM Abdelmalek, F Angriman, J Moore, K Liu… - Annals of the …, 2024 - atsjournals.org
Rationale: Outcomes for people with respiratory failure in the United States vary by patient
race and ethnicity. Invasive ventilation is an important treatment initiated based on expert …

Mortality risk factors in patients admitted with the primary diagnosis of tracheostomy complications: An analysis of 8026 patients

L Levy, A Smiley, R Latifi - … journal of environmental research and public …, 2022 - mdpi.com
Background: Tracheostomy is a procedure commonly conducted in patients undergoing
emergency admission and requires prolonged mechanical ventilation. In the present study …

Machine learning-based COVID-19 patients triage algorithm using patient-generated health data from nationwide multicenter database

MS Park, H Jo, H Lee, SY Jung, HJ Hwang - Infectious Diseases and …, 2022 - Springer
Introduction A prompt severity assessment model of patients with confirmed infectious
diseases could enable efficient diagnosis while alleviating burden on the medical system …

Differences in the Response to High-Dose Inhaled Nitric Oxide in Self-identified Black and White Individuals: A Post Hoc Analysis of the NOSARSCOVID Randomized …

NS Shetty, V Giammatteo, M Gaonkar, P Li… - American Journal of …, 2024 - atsjournals.org
Methods The protocol of the NOSARSCOVID trial has been described previously (6). Briefly,
the NOSARSCOVID trial was a multicenter, single-blind, randomized controlled trial …

[HTML][HTML] Coronary artery bypass graft surgery outcomes in the United States: impact of the coronavirus disease 2019 (COVID-19) pandemic

V Parcha, R Kalra, AM Glenn, JE Davies, S Kuranz… - JTCVS open, 2021 - Elsevier
Objective There has been a substantial decline in patients presenting for emergent and
routine cardiovascular care in the United States after the onset of the coronavirus disease …