Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …

Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) acquire mutations,
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …

Stem-Cell Aging and Pathways to Precancer Evolution | New England Journal of Medicine Skip
to main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic
stem and progenitor cells (HSPCs) that ultimately take up residence in the bone marrow …

The bone marrow microenvironment is a critical regulator of haematopoietic stem cell self-
renewal and fate. Although it is appreciated that ageing, chronic inflammation and other …

Critical-size trabecular bone defects remain challenging to treat in orthopedic clinical
practice. This study utilized a polyethylene glycol dispersion method to uniformly disperse …

Bone marrow adipocytes (BMAds) affect bone homeostasis, but the mechanism remains
unclear. Here, we showed that exercise inhibited PCNA clamp-associated factor (PCLAF) …

Myeloproliferative neoplasms are stem cell–driven cancers associated with a large burden
of morbidity and mortality. Most patients present with early-stage disease, but a substantial …

In recent years, immunotherapy has emerged as a promising strategy for treating solid
tumors, although its efficacy remains limited to a subset of patients. Transforming non …