Rates of alcohol use disorder (AUD) have increased in women by 84% over the past ten
years relative to a 35% increase in men. This substantive increase in female drinking is …

Migraine is ranked as the second highest cause of disability worldwide and the first among
women aged 15–49 years. Overall, the incidence of migraine is threefold higher among …

Observations of the disproportionate incidence of depression in women compared with men
have long preceded the recent explosion of interest in sex differences. Nonetheless, the …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) affecting young people and leading to demyelination and neurodegeneration. The …

Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

Background: Despite positive preclinical studies and two positive Phase II clinical trials, two
large Phase III clinical trials of progesterone treatment of acute traumatic brain injury (TBI) …

Progesterone has a broad spectrum of actions in the brain. Among these, the
neuroprotective effects are well documented. Progesterone neural effects are mediated by …

Neurogenic inflammation, a well-defined pathophysiologial process is characterized by the
release of potent vasoactive neuropeptides, predominantly calcitonin gene-related peptide …

Neuroactive steroids are endogenous neuromodulators synthesised in the brain that rapidly
alter neuronal excitability by binding to membrane receptors, in addition to the regulation of …

Recent FDA approval of an allopregnanolone-based treatment specifically for postpartum
depression, brexanolone, now commercially called Zulresso®, is an exciting development …